Hans Clevers Selected Research

beta Catenin

3/2010	Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
11/2009	The kinase TNIK is an essential activator of Wnt target genes.
3/2009	T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.
4/2008	Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
12/2007	Transcriptome profile of human colorectal adenomas.
7/2006	The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
6/2005	EphB receptor activity suppresses colorectal cancer progression.
5/2005	Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
3/2005	Wnt, stem cells and cancer in the intestine.
4/2004	Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.

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Hans Clevers Research Topics

Disease

108	Neoplasms (Cancer) 01/2022 - 02/2002
43	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 02/2002
18	Adenoma (Adenomas) 01/2021 - 09/2002
14	Carcinogenesis 01/2022 - 09/2002
10	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 04/2015 - 02/2002
8	Cystic Fibrosis (Mucoviscidosis) 10/2021 - 07/2013
8	Breast Neoplasms (Breast Cancer) 01/2021 - 05/2010
8	Inflammation (Inflammations) 01/2020 - 09/2007
7	Carcinoma (Carcinomatosis) 01/2022 - 09/2002
7	Colonic Neoplasms (Colon Cancer) 10/2016 - 11/2005
6	Infections 01/2022 - 01/2018
5	Adenocarcinoma 11/2022 - 10/2011
5	Pancreatic Neoplasms (Pancreatic Cancer) 12/2020 - 10/2011
4	Squamous Cell Carcinoma of Head and Neck 01/2021 - 01/2019
3	Disease Progression 11/2022 - 11/2020
3	Hyperplasia 01/2019 - 03/2009
2	Kidney Diseases (Kidney Disease) 01/2022 - 01/2020
2	Crohn Disease (Crohn's Disease) 01/2021 - 09/2007
2	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 10/2018
2	Body Weight (Weight, Body) 01/2020 - 01/2011
2	Lung Neoplasms (Lung Cancer) 01/2020 - 01/2019
2	Rectal Neoplasms (Rectal Cancer) 01/2020 - 10/2019
2	Chromosomal Instability (Chromosome Stability) 01/2019 - 02/2005
2	Neoplasm Metastasis (Metastasis) 01/2019 - 10/2018
2	Stomach Neoplasms (Stomach Cancer) 01/2019 - 06/2014
2	Influenza in Birds (Avian Flu) 11/2018 - 01/2018
2	Multiple Myeloma 01/2018 - 10/2017
2	Dry Eye Syndromes (Dry Eye Syndrome) 05/2017 - 07/2013
2	Leukemia 02/2017 - 11/2010
2	Polyps 01/2017 - 05/2002
2	Prostatic Neoplasms (Prostate Cancer) 02/2016 - 09/2014
2	Microvillus inclusion disease 10/2015 - 07/2014
2	Diarrhea 10/2015 - 01/2011
2	Type 2 Diabetes Mellitus (MODY) 01/2015 - 12/2012
1	Atrophy 01/2022
1	Liver Neoplasms (Liver Cancer) 01/2022
1	Renal Insufficiency (Renal Failure) 01/2022
1	Neoplasms, Cystic, Mucinous, and Serous 01/2022

Drug/Important Bio-Agent (IBA)

34	Pharmaceutical PreparationsIBA 01/2022 - 07/2011
26	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
24	beta CateninIBA 03/2010 - 02/2002
14	CateninsIBA 10/2020 - 10/2010
12	LigandsIBA 01/2021 - 10/2002
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 12/2010
6	Phosphotransferases (Kinase)IBA 01/2020 - 04/2009
5	DNA (Deoxyribonucleic Acid)IBA 11/2021 - 01/2014
5	TCF Transcription FactorsIBA 12/2007 - 04/2002
4	Hormones (Hormone)IBA 12/2021 - 11/2018
4	ChromatinIBA 11/2021 - 04/2008
4	Estrogen ReceptorsIBA 01/2021 - 06/2014
4	Phenobarbital (Luminal)FDA Link 01/2020 - 05/2010
4	ColforsinIBA 01/2020 - 07/2013
4	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2018 - 07/2013
4	Transcription Factors (Transcription Factor)IBA 09/2014 - 07/2003
4	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 03/2014 - 02/2002
3	CytokinesIBA 01/2022 - 11/2018
3	ErbB Receptors (EGF Receptor)IBA 11/2019 - 10/2017
3	Protein Isoforms (Isoforms)IBA 10/2017 - 10/2011
3	Calcibiotic Root Canal SealerIBA 01/2017 - 04/2014
3	Leucine (L-Leucine)FDA Link 06/2015 - 05/2010
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2022 - 01/2016
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2020
2	MucinsIBA 01/2022 - 07/2013
2	Bispecific AntibodiesIBA 01/2022 - 01/2022
2	Adenine FDA LinkGeneric 10/2021 - 01/2020
2	Peptides (Polypeptides)IBA 01/2021 - 10/2020
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2021 - 01/2020
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2020 - 09/2002
2	Fulvestrant (Faslodex)FDA Link 01/2020 - 01/2020
2	Tamoxifen FDA LinkGeneric 01/2020 - 10/2015
2	Insulin (Novolin)FDA Link 01/2020 - 01/2015
2	Irinotecan (Camptosar)FDA LinkGeneric 10/2019 - 07/2011
2	ChemokinesIBA 11/2018 - 11/2010
2	AntibodiesIBA 01/2017 - 11/2012
2	EnzymesIBA 10/2016 - 07/2012
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2015 - 05/2010
2	CarcinogensIBA 04/2015 - 06/2011
2	AzoxymethaneIBA 04/2014 - 11/2010
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 04/2014 - 11/2010
2	Sulindac (Copal)FDA LinkGeneric 01/2014 - 11/2010
2	Amino Acids FDA Link 07/2012 - 06/2002
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 11/2010 - 02/2006
2	Cyclin D1IBA 10/2010 - 08/2005
2	Messenger RNA (mRNA)IBA 09/2007 - 02/2002
2	Gamma Secretase Inhibitors and ModulatorsIBA 11/2005 - 06/2005
1	Polysaccharides (Glycans)IBA 11/2022
1	Immune Checkpoint ProteinsIBA 01/2022
1	Vancomycin FDA LinkGeneric 01/2022
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2022
1	Propranolol (Inderal)FDA LinkGeneric 01/2022
1	Organic Cation Transporter 2IBA 01/2022
1	Organic Anion TransportersIBA 01/2022
1	Cholinergic Agents (Cholinergics)IBA 01/2022

Therapy/Procedure

40	Therapeutics 01/2022 - 11/2005
10	Drug Therapy (Chemotherapy) 10/2020 - 07/2011
8	Precision Medicine 01/2022 - 07/2013
6	Transplantation 01/2020 - 07/2012
2	Heterologous Transplantation (Xenotransplantation) 01/2021 - 05/2015
2	Immunotherapy 10/2020 - 01/2018
2	Chemoprevention 01/2014 - 11/2010